Give Me Accutane or Give Me Death: The Politics of Prescriptions

teenager will tell you that acne can drive you crazy, but is it dismal enough to drive you to kill yourself? Since its market debut in 1982, enraged parents and lawyers have implicated Accutane in the hospitalizations and suicide deaths of over 200 teenagers in the US.

Accutane (isotretinoin) is one of Hoffman-LaRoche's most popular and controversial pharmaceuticals. Doctors prescribe Accutane for patients with severe nodular acne that does not respond to systemic treatments with antibiotics.

Michigan Democrat Representative Bart Stupak lost his son, BJ, to suicide in May of 2000 while the teenager was using Accutane. Since then, Congressman Stupak has led a crusade for further research to establish Accutane's risks of birth defects and psychiatric disorders like Depression and suicide.

While the safety of isotretinoin is hotly contested, there are previous Accutane users such as 21 year-old Krista Savino who view the drug as a Godsend. The antithesis of Congressman Stupak, Savino vows to do whatever she can to keep Accutane on the market. Savino sometimes experiences acne so severe that she deems her condition the "social equivalent of suicide". Accutane gives her clear skin and the confidence to leave her Home without feeling overly self-conscious.

Hoffman-LaRoche, following FDA guidelines, lists depression as a possible Accutane side effect. Notwithstanding, the link between isotretinoin and the development of Depression and/or suicide remains marred.

Like Senator Stupak, Dublin accountant Liam Grant, blames Roaccutane for the suicide death of his 20 year-old son, also named Liam. Grant alleges that his son exhibited signs of severe Depression after taking Roaccutane in the months prior to his death.

According the British newspaper, The Sunday Times, Grant has spent almost 500,000 on independent research to try to prove that Roaccutane causes Depression. Grant hired Douglas Bremner, MD of the Emory University School of Medicine to conduct the investigation. Grant hopes to use this research to force Roche Pharmaceuticals to admit liability for Liam's death.

Dr. Bremner's results, which were published in the American Journal of Psychiatry, have made strides in identifying Accutane's influence on the brain. Dr. Bremner explains that to invoke Depression, isotretinoin must affect the brain.

Dr. Bremner's Roaccutane study involved 28 healthy men and women between the ages of 18 and 50. During the investigation, brain function of the subjects was measured using positron emission tomography (PET) before and after four months of treatment with isotretinoin. Isotretinoin treatment was associated with decreased brain metabolism in the orbitofrontal cortex- the area of the brain known to mediate symptoms of Depression. Yet, there were no differences in severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment. The study concluded that isotretinoin treatment is associated with changes in brain function.

Dr. Bremner's findings call for further investigation of the drug isotretinoin. However, insufficient funding may impede such a study. The American Academy of Dermatology wants clinical trials to prove that isotretinoin causes Depression or "psychiatric events" before it encourages stronger warnings and tighter regulations of the acne drug. Yet, the FDA does not have the funding to cover the testing.

While delving into the affects of Accutane Dr. Bremner has come to agree with David J. Graham, MD, MPH- the Associate Director for science and Medicine in FDA's Office of Drug Safety. Graham warns that Accutane should be taken off the market.

Dr. David Graham paints a daunting image of how the FDA determines a drug's safely. He relates that using the Center for Drug Evaluation and Research's (CDER) standard for drug saf