"你肿么了”不是“What's wrong with you"

1. What's the matter? 你怎么了？

What's the matter? You look sad today.
你怎么了？今天看你不高兴啊！

2. What's going on? 发生什么事了？

 What's going on? you look awful!
发生什么事了?你看起来很不好！

3. Are you okay/ Are you all right? 你没事吧？你还好吧？

Are you okay with this news?
你看到这条消息的感觉还好吗?

4. Is something bothering you? 遇到什么烦心事了吗？

You don't look happy, is something bothering you?
你看起来不高兴，什么事让你心烦？

5. Why are you so glum? 你怎么闷闷不乐的呀?

-Why are you so glum ?
你为什么闷闷不乐。
- I have lost my way to my home .
我找不到回家的路。

6. You're not yourself today. 你今天有点儿不对劲啊

You're not yourself today. Maybe you should go home and get some rest.
你今天不太对劲，或许你该回家休息。

Things are never as bad as they seem.
事情往往不像看上去的那么糟。